The Mouse Anti-Abeta Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human antigen. The Mouse Anti-Abeta Antibody has been validated for the following applications: EIA, Immunoassay, and ELISA.
Description
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. It is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intra-neuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques are aggregates of the neurotoxic amyloid-beta (Abeta or Abeta) peptide. This 36-43 amino acid peptide is derived proteolytically from the transmembrane amyloid precursor protein (APP) by sequential secretase processing.
Although the normal function of Abeta is not well understood, several potential activities have been discovered including activation of kinase enzymes, protection against oxidative stress, regulation of cholesterol transport, and anti-microbial activity (potentially associated with Abeta's pro inflammatory activity)